Synthesis of 1,3-dihydro-2H-benzo[d]azepin-2-ones (microreview)

被引：4

作者：

Petuskovs, Andrejs ^{[1
]}

Shubin, Kirill ^{[1
]}

机构：

[1] Latvian Inst Organ Synth, 21 Aizkraukles St, LV-1006 Riga, Latvia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2016年 / 52卷 / 02期

关键词：

MICROWAVE-ASSISTED SYNTHESIS; REGIOSELECTIVE SYNTHESIS; CONFORMATIONAL-ANALYSIS; ANTAGONISTS; 3-BENZAZEPINONES; CYCLIZATION; INHIBITION; AGONISTS; BLOCKS;

D O I：

10.1007/s10593-016-1835-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzazepinones display a wide range of pharmacological activity, and are used for treatment of heart diseases, 1,2 cancer, 3 and Alzheimer's disease. 4 They are also found in naturally-occurring alkaloids. 5,6 Furthermore, benzazepinones are used as building blocks for synthesis of benzazepines useful for treatment of various neurological conditions, (7-13) Structurally analogous dibenzazepinones are also found in pharmaceutically-relevant organic molecules. (14,15) Here, methods of synthesis of benzazepinones hydroamination, carbopalladation, amidation, Friedel-Crafts alkylation, rearrangements with cycle enlargement are reviewed.

引用

页码：84 / 86

页数：3

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