Enantioselective desymmetrizing palladium catalyzed carbonylation reactions: the catalytic asymmetric synthesis of quaternary carbon center containing 1,3-dienes

被引：14
|
作者：
Byrne, Simon J. [2 ]
Fletcher, Anthony J. [1 ]
Hebeisen, Paul [3 ]
Willis, Michael C. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
[2] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[3] F Hoffmann La Roche Ltd, Discovery Chem, Pharmaceut Res Basel, CH-4070 Basel, Switzerland
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 04期
基金：
英国工程与自然科学研究理事会;
关键词：
ARYL; CONSTRUCTION; CYCLIZATION; ALKYLATION;
D O I：
10.1039/b923186b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A desymmetrization protocol has been used to develop a palladium catalyzed enantioselective carbonylation process. Achiral cyclic bis-alkenyltriflates are converted to their corresponding monoester derivatives with selectivities of up to 96% ee.
引用
收藏
页码：758 / 760
页数：3
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