From infancy to aging: Biological and behavioral modifiers of Fetuin-A

被引：27

作者：

Robinson, Katie N. ^{[1
,2
]}

Teran-Garcia, Margarita ^{[1
,2
,3
]}

机构：

[1] Univ Illinois, Illinois Transdisciplinary Obes Prevent Program, Bevier Hall,MC-182,905 S Goodwin Ave, Urbana, IL 61801 USA

[2] Univ Illinois, Div Nutr Sci, Bevier Hall,MC-182,905 S Goodwin Ave, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Food Sci & Human Nutr, Bevier Hall,MC-182,905 S Goodwin Ave, Urbana, IL 61801 USA

来源：

BIOCHIMIE | 2016年 / 124卷

关键词：

Fetuin-A; Alpha2-Heremans Schmid glycoprotein; AHSG; METABOLICALLY HEALTHY OBESITY; COMMUNITY-DWELLING ADULTS; FATTY LIVER-DISEASE; SERUM FETUIN; INSULIN-RESISTANCE; TYROSINE KINASE; GLYCOPROTEIN/FETUIN-A; ALCOHOL-CONSUMPTION; GENE POLYMORPHISMS; RISK-FACTORS;

D O I：

10.1016/j.biochi.2015.12.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fetuin-A is a multifunctional protein which inhibits ectopic calcification and insulin receptor phosphorylation. It may also promote insulin resistance by activation of toll-like receptor 4 pro-inflammatory cascade. Increased levels of Fetuin-A have been associated with obesity and related comorbidities such as type 2 diabetes and cardiovascular disease, therefore, it has been suggested as a potential therapeutic target for intervention. However, in addition to its role in disease pathophysiology, Fetuin-A is also important for growth and development. Thus, before evaluating Fetuin-A as a biomarker or pharmacological target, an understanding of Fetuin-A variability throughout the life cycle is essential. This manuscript reviews the current body of knowledge surrounding Fetuin-A throughout the life cycle and discuss challenges to studying Fetuin-A. (C) 2016 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.

引用

页码：141 / 149

页数：9

共 102 条

[1]

AKHOUNDI C, 1994, J BIOL CHEM, V269, P15925

[2]

[Anonymous], 2014, FASEB J

[3] Alpha2-HS glycoprotein: a protein in search of a function [J].