Enantioselective preparation of 2-substituted-1,3-dithiane 1-oxides using modified sharpless sulphoxidation procedures

被引：0

作者：

Page, PCB ^{[1
]}

Wilkes, RD ^{[1
]}

Namwindwa, ES ^{[1
]}

Witty, MJ ^{[1
]}

机构：

[1] PFIZER LTD,CENT RES,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

TETRAHEDRON | 1996年 / 52卷 / 06期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective sulphoxidation of a wide range of 2-substituted-1,3-dithianes has been carried out using modified Sharpless conditions to furnish the corresponding sulphoxides in optically enriched form, Deacylation of 2-acyl-1,3-dithiane 1-oxide derivatives allows the preparation of 2-alkyl-1,3-dithiane 1-oxides and the parent 1,3-dithiane 1-oxide itself in high enantiomeric excesses.

引用

页码：2125 / 2154

页数：30

共 93 条

[1] TRANS-1,3-DITHIANE-1,3-DIOXIDE, A NEW CHIRAL ACYL ANION EQUIVALENT FOR THE PREPARATION OF MASKED ACTIVATED ACIDS - APPLICATION TO THE SYNTHESIS OF ALPHA-HYDROXY ACID-DERIVATIVES [J].