Characterization of antibody-binding sites on proteins: Development of a knowledgebase and its applications in improving epitope prediction

被引：0

作者：

Ghate, A. D. ^{[1
]}

Bhagwat, B. U. ^{[1
]}

Bhosle, S. G. ^{[1
]}

Gadepalli, S. M. ^{[1
]}

Kulkarni-Kale, U. D. ^{[1
]}

机构：

[1] Univ Poona, Bioinformat Ctr, Pune 411007, Maharashtra, India

来源：

PROTEIN AND PEPTIDE LETTERS | 2007年 / 14卷 / 06期

关键词：

immunoinformatics; bioinformatics; conformational or discontinuous epitope; B-cell epitope prediction; antigen-antibody interactions; derived database;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immunoinformatics provides tools for reverse vaccinology and encompasses development of knowledge bases and algorithms for prediction of epitopes. AgAbDb, a database archiving molecular interactions of antigen-anti body co-crystal structures, has been developed (http://202.41.70.51:8080/agabdb2/). Analyses of antibody-binding sites on proteins helped to fine-tune the parameters for prediction of sequential and conformational B-cell epitopes.

引用

页码：531 / 535

页数：5

共 39 条

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