EGFR-RAD51 fusion in lung adenocarcinoma with systemic and intracranial response to osimertinib: A case report and review of the literature

被引：9

作者：

Sperandio, Rubens Copia ^{[1
]}

Teixeira Tostes, Francinne Luiza ^{[1
]}

Campregher, Paulo Vidal ^{[1
]}

Paes, Vitor Ribeiro ^{[1
]}

Moura, Fernando ^{[1
]}

Schvartsman, Gustavo ^{[1
]}

机构：

[1] Hosp Israelita Albert Einstein, Ctr Oncol & Hematol Einstein Familia Dayan Daycov, Sao Paulo, Brazil

来源：

LUNG CANCER | 2022年 / 166卷

关键词：

Non-small cell lung cancer; Molecular targeted therapy; Gene fusions; Molecular testing; KIF5B-EGFR FUSION; EGFR; VARIANT;

D O I：

10.1016/j.lungcan.2022.02.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Comprehensive next-generation sequencing panels are leading to detection of rare gene fusion events. EFGRRAD51 fusion is a rare oncogenic finding and clinical data for management of this condition is scarce. We report a widely metastatic non-small cell lung cancer in a never-smoker young male patient with sustained near complete systemic and intracranial response to osimertinib, a third-generation EGFR tyrosine-kinase inhibitor (TKI). We also review the available data of other TKIs in this scenario and underscore the role of comprehensive molecular testing for NSCLC.

引用

页码：94 / 97

页数：4

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