In Situ Monitoring of Intracellular Controlled Drug Release from Mesoporous Silica Nanoparticles Coated with pH-Responsive Charge-Reversal Polymer

被引：54
作者：
Zhang, Peng
Wu, Tong
Kong, Ji-Lie [1 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2014年 / 6卷 / 20期
基金：
中国国家自然科学基金;
关键词：
mesoporous silica nanoparticles; drug delivery; pH-controlled release; pH-responsive charge-reversal polymer; doxorubicin hydrochloride; GUEST MOLECULES; POLYAMIDOAMINE DENDRIMER; SUPRAMOLECULAR NANOVALVE; DELIVERY-SYSTEM; CANCER-CELLS; DOXORUBICIN; NANOSPHERE; SIRNA; BIOCOMPATIBILITY; POLYELECTROLYTE;
D O I：
10.1021/am5059519
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Therapeutic platforms such as chemotherapy that respond to physical and biological stimuli are highly desirable for effective cancer therapy. In this study, pH-responsive charge-reversal, polymer-coated mesoporous silica nanoparticles [PAH-cit/APTES-MSNs; PAH-cit refers to poly(allylamine)-citraconic anhydride; APTES refers to (3-aminopropyl)triethoxysilane] were synthesized for application as drug-delivery systems for the treatment of malignant cells. Confocal laser scanning microscopy (CLSM) revealed that the PAH-cit/APTES-MSNs nanocomposite effectively delivered and released doxorubicin hydrochloride to the nucleus of HeLa (human cervical carcinoma) cells. Additionally, the real-time dynamic drug-release process was monitored by CLSM. The current pH-controlled-smart-release platform holds promise in drug-delivery and cancer therapy-related applications.
引用
收藏
页码：17446 / 17453
页数：8
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