A mild approach to the synthesis of sn-glycerol 1,2-di-γ-linolenate 3-palmitate

被引：0
作者：
Rejzek, M
Vacek, M
Wimmer, Z
机构：
[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CZ-16610 Prague 6, Czech Republic
[2] Inst Chem Technol, CZ-16028 Prague 6, Czech Republic
来源：
HELVETICA CHIMICA ACTA | 2000年 / 83卷 / 10期
关键词：
D O I：
10.1002/1522-2675(20001004)83:10<2756::AID-HLCA2756>3.0.CO;2-I
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A synthetic approach comprising several studied modifications was applied to the preparation of sn-glycerol 1,2-di-gamma -linolenate 3-palmitate (4). Thereby, a convenient and mild synthetic method was elaborated. affording 4 from 1,2-O-isopropylidene-sn-glycerol (1) in an average yield of 65-75% and analytically acceptable purity.
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页码：2756 / 2760
页数：5
相关论文
共 14 条
[1]  
AITZETMULLER K, 1992, HRC-J HIGH RES CHROM, V15, P219
[2]   SYNTHESIS AND CHARACTERIZATION OF TRIACYLGLYCEROLS CONTAINING LINOLEATE AND LINOLENATE [J].
AWL, RA ;
FRANKEL, EN ;
WEISLEDER, D .
LIPIDS, 1989, 24 (10) :866-872
[3]   SYNTHESIS OF C-18 MIXED ACID DIACYL-SN-GLYCEROL ENANTIOMERS [J].
BUCHNEA, D .
LIPIDS, 1971, 6 (10) :734-&
[4]  
Eritsland J, 1998, FOURTH INTERNATIONAL CONGRESS ON ESSENTIAL FATTY ACIDS AND EICOSANOIDS, P243
[5]   NUTRITIONAL AND MEDICAL IMPORTANCE OF GAMMA-LINOLENIC ACID [J].
HORROBIN, DF .
PROGRESS IN LIPID RESEARCH, 1992, 31 (02) :163-194
[6]   GAMMA-AMINOBUTYRIC ACID-ESTERS .2. SYNTHESIS, BRAIN UPTAKE, AND PHARMACOLOGICAL PROPERTIES OF LIPID ESTERS OF GAMMA-AMINOBUTYRIC ACID [J].
JACOB, JN ;
SHASHOUA, VE ;
CAMPBELL, A ;
BALDESSARINI, RJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (01) :106-110
[7]  
JENSEN RG, 1976, ADV LIPID RES, V14, P213
[8]  
Jiang W, 1998, FOURTH INTERNATIONAL CONGRESS ON ESSENTIAL FATTY ACIDS AND EICOSANOIDS, P303
[9]  
KODALI DR, 1987, J LIPID RES, V28, P464
[10]  
Nordoy A, 1998, FOURTH INTERNATIONAL CONGRESS ON ESSENTIAL FATTY ACIDS AND EICOSANOIDS, P256
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