Effects of flavonoids on tongue squamous cell carcinoma

被引：15

作者：

Gutierrez-Venegas, Gloria ^{[1
]}

Sanchez-Carballido, Manuel Alejandro ^{[1
]}

Delmas Suarez, Claire ^{[1
]}

Gomez-Mora, Juan Arturo ^{[1
]}

Bonneau, Noemie ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Fac Odontol, Div Estudios Posgrad & Invest, Lab Bioquim, Mexico City 04510, DF, Mexico

来源：

CELL BIOLOGY INTERNATIONAL | 2020年 / 44卷 / 03期

关键词：

cancer; flavonoids; half maximal inhibitory concentration; oral squamous cell carcinoma; 1-OXIDE-INDUCED ORAL CARCINOGENESIS; GREEN TEA POLYPHENOLS; HUMAN-PAPILLOMAVIRUS HPV; IN-VITRO CYTOTOXICITY; CANCER-CELLS; EPIGALLOCATECHIN GALLATE; ANTIOXIDANT ACTIVITY; INDUCED APOPTOSIS; TONSILLAR CANCER; CYCLE ARREST;

D O I：

10.1002/cbin.11266

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Squamous cell carcinoma (SCC) of the tongue is associated with tobacco use, alcohol abuse, and human papillomavirus (HPV) infections. While clinical outcomes have recently improved for HPV-positive patients in general, 50% of patients suffering from tongue cancer die within 5 years of being diagnosed. Flavonoids are secondary plant metabolites with a wide range of biological activities including antioxidant, anti-inflammatory, and anticancer activities. Flavonoids have generated high interest as therapeutic agents owing to their low toxicity and their effects on a large variety of cancer cell types. In this literature review, we evaluate the actions of flavonoids on SCC of the tongue demonstrated in both in vivo and in vitro models.

引用

页码：686 / 720

页数：35

共 122 条

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