Expeditious Synthesis of Highly Substituted Indolizinones via a Palladium-Catalyzed Domino Sequence

被引：48

作者：

Kim, Ikyon ^{[1
]}

Kim, Kyungsun ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Med Chem Res Ctr, Taejon 305600, South Korea

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 11期

关键词：

EFFICIENT SYNTHESIS; ORGANIC HALIDES; O-ALKYNYLPHENOLS; STRATEGIC USE; CONSTRUCTION; HETEROCYCLES; CYCLIZATION; ALKYNES; BONDS; ARYL;

D O I：

10.1021/ol1006778

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct one-pot approach to polysubstituted indolizinones from tertiary propargylic alcohols using a palladium-catalyzed domino process involving aminopalladation, reductive elimination, and 1,2-shift is described.

引用

页码：2500 / 2503

页数：4

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