Objective: The aim of this study was to investigate the related factors in wound healing and to provide clinical evidence for the prevention and treatment of skin wounds, especially refractory wounds. Methods: Five hundred sixty-seven wound cases that were treated at the Department of Plastic and Cosmetic Surgery of Xing iao Hospital in Chongqing, China, from January 2003 to December 2016, were retrospectively reviewed, and the related factors were analyzed using Logistic regression. Results: Single factor analysis of the related factors showed that 7 related factors, namely, age, wound area, wound type, cause of wound formation, surgical treatment, the time from wound formation to surgical treatment and the use of vacuum sealing drainage (VSD), were the influencing factors. Logistic regression analysis showed that there were no significant differences in age, wound type, cause of wound formation or surgical treatment (P > 0.05); however, the time from wound formation to surgical treatment and the use of VSD were the most influential factors affecting wound healing (P < 0.05). Conclusion: The efficacy of wound healing is affected by many factors. According to the type of wound, different treatment plans should be established, the infection should be prevented, and attention should be paid to the treatment time, such that wounds are treated as soon as possible. For the conditioned wound, the technique of VSD can be applied to shorten the healing time, promote wound healing and improve the healing rate of the wound.