Voltage-dependent anion-selective channel (VDAC) in the plasma membrane

被引：136

作者：

De Pinto, Vito ^{[1
]}

Messina, Angela ^{[1
]}

Lane, Darius J. R. ^{[2
]}

Lawen, Alfons ^{[2
]}

机构：

[1] Univ Catania, Dept Chem Sci, Ist Nazl Biomembrane & Biosistemi, Sez Catania, I-95125 Catania, Italy

[2] Monash Univ, Sch Biomed Sci, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

FEBS LETTERS | 2010年 / 584卷 / 09期

关键词：

Voltage-dependent anion-selective channel; Mitochondria; Plasma membrane; NADH-oxidoreductase; Dynamic membrane protein redistribution; HUMAN B-LYMPHOCYTES; MITOCHONDRIAL OUTER-MEMBRANE; PORIN; 31; HL; SARCOPLASMIC-RETICULUM; ENDOPLASMIC-RETICULUM; SKELETAL-MUSCLE; HIPPOCAMPAL-NEURONS; NADH-OXIDOREDUCTASE; PROTEOMIC ANALYSIS; LARGE-CONDUCTANCE;

D O I：

10.1016/j.febslet.2010.02.049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Voltage-dependent anion channels (VDACs) have originally been characterized as mitochondrial porins. Starting in the late 1980s, however, evidence began to accumulate that VDACs can also be expressed in plasma membranes. In this review, we briefly revisit the historical milestones in the discovery of plasma membrane-bound VDAC, and we critically analyze the evidence for VDAC plasma membrane localization obtained from various purification strategies and recently from plasma membrane proteomics studies. We discuss the possible biological function and relevance of VDAC in the plasma membrane and finally discuss a hypothetical model of how VDAC may be targeted to the plasma membrane. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1793 / 1799

页数：7

共 77 条

[1] Voltage-dependent anion channels (VDAC) in the plasma membrane play a critical role in apoptosis in differentiated hippocampal neurons but not in neural stem cells [J].