Synthetic Skin-Permeable Proteins Enabling Needleless Immunization

被引：45
作者：
Huang, Yongzhuo [1 ]
Park, Yoon Shin [1 ]
Moon, Cheol [1 ]
David, Allan E. [1 ]
Chung, Hee Sun [1 ]
Yang, Victor C. [1 ,2 ]
机构：
[1] Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA
[2] Tianjin Univ, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 15期
关键词：
antigens; drug delivery; percutaneous absorption; protein modifications; vaccination; TRANSCUTANEOUS IMMUNIZATION; HUMAN KERATINOCYTES; IN-VITRO; DELIVERY; PEPTIDE; PROTAMINE; MEMBRANES; IMMUNITY; MUCOSAL;
D O I：
10.1002/anie.200906153
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
More than skin-deep: Synthetic skin-permeable antigens are constructed by conjugation of the cell-penetrating lowmolecular-weight protamine (LMWP) peptide to protein antigens through cleavable disulfide bonds. Such artificial antigens can penetrate the stratum corneum barrier (see picture), thereby sensitizing the skin immune system to elicit robust immune responses. (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2724 / 2727
页数：4
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