Controversy: Sensitization against quaternary ammonium compounds is involved in allergic reactions to neuromuscular blocking agents

被引：2

作者：

Mertes, P. M. ^{[1
,2
]}

Regnier, M. -A. ^{[1
,2
]}

Hasdenteufel, F. ^{[3
]}

Gueant-Rodriguez, R. M. ^{[4
,5
,6
]}

Mouton-Faivre, C. ^{[1
,2
]}

Malinovsky, J. M. ^{[5
,6
]}

Gueant, J. -L ^{[4
,5
,6
]}

Kanny, G. ^{[3
]}

机构：

[1] Hop Cent, CHU Nancy, Serv Anesthesie Reanimat Chirurg, F-54035 Nancy, France

[2] Fac Med Vandoeuvre Nancy, U961, F-54505 Vandoeuvre Les Nancy, France

[3] Hop Cent, CHU Nancy, Serv Med Interne Immunol Clin Allergol, F-54035 Nancy, France

[4] CHU Brabois, Lab Biochem Biol Mol Nutr Metab, F-54511 Vandoeuvre Les Nancy, France

[5] Fac Med Vandoeuvre Nancy, U724, F-54505 Vandoeuvre Les Nancy, France

[6] Hop Maison Blanche, Pole URAD, CHU Remis, Serv Anesthesie & Reanimat, F-51092 Reims, France

来源：

REVUE FRANCAISE D ALLERGOLOGIE | 2010年 / 50卷 / 03期

关键词：

Anesthesia; Allergy; Neuromuscular blocking agents; Quaternary ammonium compounds; Cross-reactivity; Pholcodine; HYPERSENSITIVITY REACTIONS; ADVERSE-REACTIONS; ANESTHESIA; ANAPHYLAXIS; ANTIBODIES; FRANCE; IGE; SWEDEN; DRUGS;

D O I：

10.1016/j.reval.2010.01.022

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Allergic reactions to neuromuscular blocking agents (NMBAs) remain a major issue in anaesthesia NMBAs possess two quaternary ammonium ions which are necessary for their biological properties but which are also part of the epitope recognised by specific IgEs Immediate hypersensitivity allergic reactions occurring on induction of anesthesia with first exposure to NMBA has led to the hypothesis of pre-existent cross-reactive sensitisation following exposure to compounds in the environment which have a quaternary ammonium determinant Pholcodine is one of the substances which has been recognised as being potentially responsible for this sensitization However, the most recent epidemiologic studies have suggested that other substances which remained to be identified might equally be involved (C) 2010 Elsevier Masson SAS All rights reserved.

引用

页码：174 / 178

页数：5

共 27 条

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