Increased Systemic Inflammation and Gut Permeability Among Women With Treated HIV Infection in Rural Uganda

被引：40

作者：

Siedner, Mark J. ^{[1
,2
,7
]}

Zanni, Markella ^{[1
,2
]}

Tracy, Russell P. ^{[4
]}

Kwon, Douglas S. ^{[1
,2
]}

Tsai, Alexander C. ^{[1
,2
]}

Kakuhire, Bernard ^{[7
]}

Hunt, Peter W. ^{[5
]}

Okello, Samson ^{[3
,6
,7
]}

机构：

[1] Harvard Med Sch, Boston, MA USA

[2] Massachusetts Gen Hosp, Boston, MA 02114 USA

[3] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

[4] Univ Vermont, Burlington, VT 05405 USA

[5] Univ Calif San Francisco, San Francisco, CA 94143 USA

[6] Univ Virginia, Charlottesville, VA USA

[7] Mbarara Univ Sci & Technol, Mbarara, Uganda

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 218卷 / 06期

基金：

美国国家卫生研究院;

关键词：

HIV; inflammation; gut permeability; Uganda; sub-Saharan Africa; sex; women; ACUTE MYOCARDIAL-INFARCTION; IMMUNE ACTIVATION MARKERS; ANTIRETROVIRAL THERAPY; T-CELL; INDIVIDUALS; REPLICATION; PERSISTENT; MORTALITY; RISK;

D O I：

10.1093/infdis/jiy244

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In a cohort of human immunodeficiency virus (HIV)-infected individuals and age-and sex-matched HIV-uninfected comparators, we assessed soluble CD14 (sCD14), sCD163, interleukin 6, intestinal fatty acid binding protein (IFAPB), and high-sensitivity C-reactive protein (hs-CRP) levels. The median age was 51 years. Among HIV-positive individuals, the median antiretroviral therapy (ART) duration was 7 years, the median CD4(+) T-cell count was 433 cells/mu L, and 86% had an undetectable viral load. Although HIV-positive individuals had higher sCD14, IFABP, and hs-CRP levels, we found evidence of interaction by sex, such that HIV-positive women had greater differences from HIV-negative women, compared with differences between HIV-positive men and HIV-negative men. In models restricted to HIV-positive individuals, women had higher levels of all 5 biomarkers than men.

引用

页码：922 / 926

页数：5

共 15 条

[1] Angiotensin Converting Enzyme Inhibitor and HMG-CoA Reductase Inhibitor as Adjunct Treatment for Persons with HIV Infection: A Feasibility Randomized Trial [J].

Baker, Jason V. ;

Hullsiek, Kathleen Huppler ;

Prosser, Rachel ;

Duprez, Daniel ;

Grimm, Richard ;

Tracy, Russell P. ;

Rhame, Frank ;

Henry, Keith ;

Neaton, James D. .

PLOS ONE, 2012, 7 (10)

[2] Persistent Microbial Translocation and Immune Activation in HIV-1-Infected South Africans Receiving Combination Antiretroviral Therapy [J].

Cassol, Edana ;

Malfeld, Susan ;

Mahasha, Phetole ;

van der Merwe, Schalk ;

Cassol, Sharon ;

Seebregts, Chris ;

Alfano, Massimo ;

Poli, Guido ;

Rossouw, Theresa .

JOURNAL OF INFECTIOUS DISEASES, 2010, 202 (05) :723-733

[3] Comparison of Ischemic Stroke Incidence in HIV-Infected and Non-HIV-Infected Patients in a US Health Care System [J].

Chow, Felicia C. ;

Regan, Susan ;

Feske, Steven ;

Meigs, James B. ;

Grinspoon, Steven K. ;

Triant, Virginia A. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2012, 60 (04) :351-358

[4] Inflammation, Coagulation and Cardiovascular Disease in HIV-Infected Individuals [J].

Duprez, Daniel A. ;

Neuhaus, Jacqueline ;

Kuller, Lewis H. ;

Tracy, Russell ;

Belloso, Waldo ;

De Wit, Stephane ;

Drummond, Fraser ;

Lane, H. Clifford ;

Ledergerber, Bruno ;

Lundgren, Jens ;

Nixon, Daniel ;

Paton, Nicholas I. ;

Prineas, Ronald J. ;

Neaton, James D. .

PLOS ONE, 2012, 7 (09)

[5] Serum Immune Activation Markers Are Persistently Increased in Patients with HIV Infection after 6 Years of Antiretroviral Therapy despite Suppression of Viral Replication and Reconstitution of CD4+ T Cells [J].

French, Martyn A. ;

King, Martin S. ;

Tschampa, Jean M. ;

da Silva, Barbara A. ;

Landay, Alan L. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 200 (08) :1212-1215

[6] Rosuvastatin Reduces Vascular Inflammation and T-cell and Monocyte Activation in HIV-Infected Subjects on Antiretroviral Therapy [J].

Funderburg, Nicholas T. ;

Jiang, Ying ;

Debanne, Sara M. ;

Labbato, Danielle ;

Juchnowski, Steven ;

Ferrari, Brian ;

Clagett, Brian ;

Robinson, Janet ;

Lederman, Michael M. ;

McComsey, Grace A. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2015, 68 (04) :396-404

[7] Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy [J].

Hunt, Peter W. ;

Brenchley, Jason ;

Sinclair, Elizabeth ;

McCune, Joseph M. ;

Roland, Michelle ;

Page-Shafer, Kimberly ;

Hsue, Priscilla ;

Emu, Brinda ;

Krone, Melissa ;

Lampiris, Harry ;

Douek, Daniel ;

Martin, Jeffrey N. ;

Deeks, Steven G. .

JOURNAL OF INFECTIOUS DISEASES, 2008, 197 (01) :126-133

[8] Immunologic Biomarkers, Morbidity, and Mortality in Treated HIV Infection [J].

Hunt, Peter W. ;

Lee, Sulggi A. ;

Siedner, Mark J. .

JOURNAL OF INFECTIOUS DISEASES, 2016, 214 :S44-S50

[9] Plasma Soluble CD163 Level Independently Predicts All-Cause Mortality in HIV-1-Infected Individuals [J].

Knudsen, Troels Bygum ;

Ertner, Gideon ;

Petersen, Janne ;

Moller, Holger Jon ;

Moestrup, Soren K. ;

Eugen-Olsen, Jesper ;

Kronborg, Gitte ;

Benfield, Thomas .

JOURNAL OF INFECTIOUS DISEASES, 2016, 214 (08) :1198-1204

[10] HIV Replication and Immune Status Are Independent Predictors of the Risk of Myocardial Infarction in HIV-Infected Individuals [J].

Lang, Sylvie ;

Mary-Krause, Murielle ;

Simon, Anne ;

Partisani, Marialuisa ;

Gilquin, Jacques ;

Cotte, Laurent ;

Boccara, Franck ;

Costagliola, Dominique .

CLINICAL INFECTIOUS DISEASES, 2012, 55 (04) :600-607

← 1 2 →