Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based Hydrogen-Producing Agent

被引:11
作者
Usui, Noriyoshi [1 ,2 ,3 ,4 ]
Matsumoto-Miyai, Kazumasa [5 ]
Koyama, Yoshihisa [1 ,4 ]
Kobayashi, Yuki [6 ]
Nakamura, Yukiko [1 ,4 ]
Kobayashi, Hikaru [6 ]
Shimada, Shoichi [1 ,2 ,3 ,4 ]
机构
[1] Osaka Univ, Grad Sch Med, Dept Neurosci & Cell Biol, Suita, Japan
[2] Osaka Univ, United Grad Sch Child Dev, Suita, Japan
[3] Osaka Univ, Global Ctr Med Engn & Informat, Suita, Japan
[4] Osaka Psychiat Res Ctr, Osaka Psychiat Med Ctr, Addict Res Unit, Osaka, Japan
[5] Osaka Prefecture Univ, Osaka Univ, Grad Sch Comprehens Rehabil, Osaka, Suita, Japan
[6] Osaka Univ, Inst Sci & Ind Res, Suita, Japan
基金
日本科学技术振兴机构;
关键词
maternal immune activation (MIA); neurodevelopmental disorders (NDDs); autism spectrum disorder (ASD); ultrasonic vocalization (USV); social communication; inflammation; silicon; hydrogen; OXIDATIVE STRESS; AUTISM; VOCALIZATIONS; SUPERFAMILY; ANTIOXIDANT; EXPOSURE; MICE;
D O I
10.3389/fpsyt.2022.872302
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we have developed a silicon (Si)-based hydrogen-producing antioxidant (Si-based agent) that continuously and effectively produces hydrogen in the body. Medical hydrogen is known to have antioxidative, anti-inflammatory, and antiapoptotic effects, therefore we applied our Si-based agent as a potential therapeutic agent to MIA. Using a MIA mouse model, we found that the Si-based agent improved the social communication of MIA offspring mice. We also found that the Si-based agent suppressed the expressions of inflammation-associated genes Ifna1 and Il-6 in the mouse brain. These results demonstrate that the Si-based agent is an effective prophylactic agent against MIA during pregnancy, suggesting that our Si-based agent may be a preventative or therapeutic agent for ASD and other disease risks in child health suppressing MIA damage.
引用
收藏
页数:8
相关论文
共 40 条
[1]   PSYCHOPHYSIOLOGICAL REACTIONS IN HUMANS DURING AN OPEN SEA DIVE TO 500 M WITH A HYDROGEN-HELIUM-OXYGEN MIXTURE [J].
ABRAINI, JH ;
GARDETTECHAUFFOUR, MC ;
MARTINEZ, E ;
ROSTAIN, JC ;
LEMAIRE, C .
JOURNAL OF APPLIED PHYSIOLOGY, 1994, 76 (03) :1113-1118
[2]   Signalling pathways of the TNF superfamily: A double-edged sword [J].
Aggarwal, BB .
NATURE REVIEWS IMMUNOLOGY, 2003, 3 (09) :745-756
[3]   The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring [J].
Choi, Gloria B. ;
Yim, Yeong S. ;
Wong, Helen ;
Kim, Sangdoo ;
Kim, Hyunju ;
Kim, Sangwon V. ;
Hoeffer, Charles A. ;
Littman, Dan R. ;
Huh, Jun R. .
SCIENCE, 2016, 351 (6276) :933-939
[4]   Advancing the understanding of autism disease mechanisms through genetics [J].
de la Torre-Ubieta, Luis ;
Won, Hyejung ;
Stein, Jason L. ;
Geschwind, Daniel H. .
NATURE MEDICINE, 2016, 22 (04) :345-361
[5]   Maternal immune activation: Implications for neuropsychiatric disorders [J].
Estes, Myka L. ;
McAllister, A. Kimberley .
SCIENCE, 2016, 353 (6301) :772-777
[6]   Changes in maximal performance of inspiratory and skeletal muscles during and after the 7.1-MPa Hydra 10 record human dive [J].
Fontanari, P ;
Badier, M ;
Guillot, C ;
Tomei, C ;
Burnet, H ;
Gardette, B ;
Jammes, Y .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2000, 81 (04) :325-328
[7]  
Fu BQ, 2017, IMMUNITY, V47, P1100, DOI [10.1016/j.immuni.2017.11.018, 10.15585/mmwr.ss6904a1]
[8]   Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2 [J].
Garcia-Flores, Valeria ;
Romero, Roberto ;
Xu, Yi ;
Theis, Kevin ;
Arenas-Hernandez, Marcia ;
Miller, Derek ;
Peyvandipour, Azam ;
Galaz, Jose ;
Levenson, Dustyn ;
Bhatti, Gaurav ;
Gershater, Meyer ;
Pusod, Errile ;
Kracht, David ;
Florova, Violetta ;
Leng, Yaozhu ;
Tao, Li ;
Faucett, Megan ;
Para, Robert ;
Hsu, Chaur-Dong ;
Zhang, Gary ;
Tarca, Adi ;
Pique-Regi, Roger ;
Gomez-Lopez, Nardhy .
NATURE COMMUNICATIONS, 2022, 13 (01)
[9]   Early or Late Gestational Exposure to Maternal Immune Activation Alters Neurodevelopmental Trajectories in Mice: An Integrated Neuroimaging, Behavioral, and Transcriptional Study [J].
Guma, Elisa ;
Bordignon, Pedro do Couto ;
Devenyi, Gabriel A. ;
Gallino, Daniel ;
Anastassiadis, Chloe ;
Cvetkovska, Vedrana ;
Barry, Amadou D. ;
Snook, Emily ;
Germann, Jurgen ;
Greenwood, Celia M. T. ;
Misic, Bratislav ;
Bagot, Rosemary C. ;
Chakravarty, M. Mallar .
BIOLOGICAL PSYCHIATRY, 2021, 90 (05) :328-341
[10]   Maternal Inflammation and Neurodevelopmental Programming: A Review of Preclinical Outcomes and Implications for Translational Psychiatry [J].
Gumusoglu, Serena B. ;
Stevens, Hanna E. .
BIOLOGICAL PSYCHIATRY, 2019, 85 (02) :107-121