Haemoglobin and haemoglobinopathies at the forefront in the 21st century

被引：0

作者：

Beuzard, Yves ^{[1
]}

机构：

[1] IMRB Hop Henri Mondor, Inserm U955, Creteil, France

来源：

HEMATOLOGIE | 2021年 / 27卷 / 02期

关键词：

Hemoglobin; sickle cell dispose; thalassemia; SICKLE-CELL-DISEASE; GENE-THERAPY; BETA-HEMOGLOBINOPATHIES; HYDROGEN-SULFIDE; CARBON-MONOXIDE; TRANSPLANTATION; MUTATIONS; TREAT; RISK;

D O I：

10.1684/hma.2021.1647

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review aims to take stock of recent advances and perspectives in various fields (physiology, physiopathology, and therapy) of haemoglobin and haemoglobin disorders. This includes gaseous signalling molecules (NO, CO, H2S), blood flow changes in microcirculatory units, metabolic regulation of red blood cells, etc., the regulatory stages that determine the expression and intracellular concentration of a model protein, control of differentiation and cell mass of a tissue or organ, gene switching during development and its therapeutic reversion, comprehensive care of patients with sickle cell disease or beta-thalassaemia, targeted therapies, allo-transplantation, and gene therapy (gene addition or gene editing)

引用

页码：55 / 77

页数：23

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