Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity

被引：30
作者：
Lin, Shudai [1 ,2 ,3 ]
Zhang, Li [1 ,2 ,3 ,4 ]
Luo, Wen [1 ,2 ,3 ]
Zhang, Xiquan [1 ,2 ,3 ]
机构：
[1] South China Agr Univ, Coll Anim Sci, Dept Anim Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China
[2] Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Guangdong, Peoples R China
[3] Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China
[4] Guangdong Ocean Univ, Coll Agr, Zhanjiang 524088, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 01期
关键词：
antisense promoter; location; characteristics; activity; influencing factors; HUMAN BIDIRECTIONAL PROMOTERS; LONG NONCODING RNA; GENOME-WIDE ANALYSIS; GENE-EXPRESSION; DNA METHYLATION; MESSENGER-RNA; HEPATOCELLULAR-CARCINOMA; L1; RETROTRANSPOSON; FACTOR-BINDING; HUMAN-CELLS;
D O I：
10.3390/ijms17010009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recently, an increasing number of studies on natural antisense transcripts have been reported, especially regarding their classification, temporal and spatial expression patterns, regulatory functions and mechanisms. It is well established that natural antisense transcripts are produced from the strand opposite to the strand encoding a protein. Despite the pivotal roles of natural antisense transcripts in regulating the expression of target genes, the transcriptional mechanisms initiated by antisense promoters (ASPs) remain unknown. To date, nearly all of the studies conducted on this topic have focused on the ASP of a single gene of interest, whereas no study has systematically analyzed the locations of ASPs in the genome, ASP activity, or factors influencing this activity. This review focuses on elaborating on and summarizing the characteristics of ASPs to extend our knowledge about the mechanisms of antisense transcript initiation.
引用
收藏
页数：17
相关论文
共 98 条
[41]   HIV-1-encoded antisense RNA suppresses viral replication for a prolonged period [J].
Kobayashi-Ishihara, Mie ;
Yamagishi, Makoto ;
Hara, Takuma ;
Matsuda, Yuka ;
Takahashi, Ryutaro ;
Miyake, Ariko ;
Nakano, Kazumi ;
Yamochi, Tadanori ;
Ishida, Takaomi ;
Watanabe, Toshiki .
RETROVIROLOGY, 2012, 9
[42]   Genome-wide natural antisense transcription: coupling its regulation to its different regulatory mechanisms [J].
Lapidot, Michal ;
Pilpel, Yitzhak .
EMBO REPORTS, 2006, 7 (12) :1216-1222
[43]  
Lau S. L., 2005, THESIS U HONG KONG H
[44]   Divergent transcription is associated with promoters of transcriptional regulators [J].
Lepoivre, Cyrille ;
Belhocine, Mohamed ;
Bergon, Aurelie ;
Griffon, Aurelien ;
Yammine, Miriam ;
Vanhille, Laurent ;
Zacarias-Cabeza, Joaquin ;
Garibal, Marc-Antoine ;
Koch, Frederic ;
Maqbool, Muhammad Ahmad ;
Fenouil, Romain ;
Loriod, Beatrice ;
Holota, Helene ;
Gut, Marta ;
Gut, Ivo ;
Imbert, Jean ;
Andrau, Jean-Christophe ;
Puthier, Denis ;
Spicuglia, Salvatore .
BMC GENOMICS, 2013, 14
[45]   The role of chromatin during transcription [J].
Li, Bing ;
Carey, Michael ;
Workman, Jerry L. .
CELL, 2007, 128 (04) :707-719
[46]   An antisense promoter in mouse L1 retrotransposon open reading frame-1 initiates expression of diverse fusion transcripts and limits retrotransposition [J].
Li, Jingfeng ;
Kannan, Manoj ;
Trivett, Anna L. ;
Liao, Hongling ;
Wu, Xiaolin ;
Akagi, Keiko ;
Symer, David E. .
NUCLEIC ACIDS RESEARCH, 2014, 42 (07) :4546-4562
[47]   Delta-like 4 mRNA is regulated by adjacent natural antisense transcripts [J].
Li, Keguo ;
Chowdhury, Tamjid ;
Vakeel, Padmanabhan ;
Koceja, Christopher ;
Sampath, Venkatesh ;
Ramchandran, Ramani .
VASCULAR CELL, 2015, 7
[48]   Genome-Wide Mapping of DNA Methylation in Chicken [J].
Li, Qinghe ;
Li, Ning ;
Hu, Xiaoxiang ;
Li, Jinxiu ;
Du, Zhuo ;
Chen, Li ;
Yin, Guangliang ;
Duan, Jinjie ;
Zhang, Haichao ;
Zhao, Yaofeng ;
Wang, Jun ;
Li, Ning .
PLOS ONE, 2011, 6 (05)
[49]   Transcription factor binding and modified histones in human bidirectional promoters [J].
Lin, Jane M. ;
Collins, Patrick J. ;
Trinklein, Nathan D. ;
Fu, Yutao ;
Xi, Hualin ;
Myers, Richard M. ;
Weng, Zhiping .
GENOME RESEARCH, 2007, 17 (06) :818-827
[50]   Genome-wide analysis of the transcription factor binding preference of human bi-directional promoters and functional annotation of related gene pairs [J].
Liu, Bingchuan ;
Chen, Jiajia ;
Shen, Bairong .
BMC SYSTEMS BIOLOGY, 2011, 5
12345678910