Impact of foods enriched with n-3 long-chain polyunsaturated fatty acids on erythrocyte n-3 levels and cardiovascular risk factors

被引:96
作者
Murphy, Karen J.
Meyer, Barbara J.
Mori, Trevor A.
Burke, Valerie
Mansour, Jackie
Patch, Craig S.
Tapsell, Linda C.
Noakes, Manny
Clifton, Peter A.
Barden, Anne
Puddey, Ian B.
Beilin, Lawrence J.
Howe, Peter R. C. [1 ]
机构
[1] Univ S Australia, Nutr Physiol Res Ctr, Div Hlth Sci, Adelaide, SA 5000, Australia
[2] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA 5000, Australia
[3] Univ Wollongong, Smart Foods Ctr, Wollongong, NSW 2522, Australia
[4] Univ Western Australia, Sch Med & Pharmacol, Royal Perth Hosp Unit, Perth, WA 6000, Australia
[5] CSIRO, Div Hlth Sci & Nutr, Adelaide, SA 5000, Australia
关键词
functional foods; n-3 long-chain polyunsaturated fatty acids; processed foods; dietary intervention; cardiovascular disease;
D O I
10.1017/S000711450747252X
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Consumption of fish or fish oils rich in the n-3 long chain PUFA EPA and DHA may improve multiple risk factors for CVD. The objective of this study was to determine whether regular consumption of foods enriched with n-3 long-chain PUFA can improve n-3 long-chain PUFA status (erythrocytes) and cardiovascular health. Overweight volunteers with high levels of triacylglycerols (TG; > 1.6 mmol/l) were enrolled in a 6-month dietary intervention trial conducted in Adelaide (n 47) and Perth (it 39), and randomised to consume control foods or n-3-enriched foods to achieve an EPA + DHA intake of 1 g/d. Test foods were substituted for equivalent foods in their regular diet. Erythrocyte fatty acids. plasma TG and other CVD risk factors were monitored at 0, 3 and 6 months. There were no significant differences between groups for blood pressure. arterial compliance, glucose, insulin, lipids, C-reactive protein (CRP) or urinary 11-dehydro-thromboxane B-2 (TXB2) over 6 months, even though regular consumption of n-3-enriched foods increased EPA + DHA intake from 0.2 to 1.0g/d. However, the n-3 long-chain PUFA content of erythrocytes increased by 35 and 53 % at 3 and 6 months, respectively, in subjects consuming the n-3-enriched foods. These increases were positively associated with measures of arterial compliance and negatively associated with serum CRP and urinary 1-dehydro-TXB2 excretion. Sustainable increases in dietary intakes and erythrocyte levels of n-3 long-chain PUFA can be achieved through regular consumption of suitably enriched processed foods. Such increases may be associated with reduced CV risk.
引用
收藏
页码:749 / 757
页数:9
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