An issue of tissues: divining the split personalities of selective estrogen receptor modulators

被引：54

作者：

McKenna, N ^{[1
]}

O'Malley, BW ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 09期

关键词：

D O I：

10.1038/79637

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of coregulators and other recent advances in our understanding of the molecular biology of nuclear receptor action have generated expectations that these exciting basic advances will be translated into new diagnostic and therapeutic approaches for endocrine diseases such as breast cancer.

引用

页码：960 / 962

页数：3

共 17 条

[1] AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer [J].

Anzick, SL ;

Kononen, J ;

Walker, RL ;

Azorsa, DO ;

Tanner, MM ;

Guan, XY ;

Sauter, G ;

Kallioniemi, OP ;

Trent, JM ;

Meltzer, PS .

SCIENCE, 1997, 277 (5328) :965-968

[2]

*ATL HILT TOW, 2000, ER HOP DEP DEF BREAS

[3]

Bautista S, 1998, CLIN CANCER RES, V4, P2925

[4]

Endoh H, 1999, MOL CELL BIOL, V19, P5363

[5] Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas [J].

Ghadimi, BM ;

Schröck, E ;

Walker, RL ;

Wangsa, D ;

Jauho, A ;

Meltzer, PS ;

Ried, T .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (02) :525-536

[6]

GRAHAM JD, 1998, KEYST S NUCL REC GEN

[7]

Kurebayashi J, 2000, CLIN CANCER RES, V6, P512

[8] A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex [J].

Lanz, RB ;

McKenna, NJ ;

Onate, SA ;

Albrecht, U ;

Wong, JM ;

Tsai, SY ;

Tsai, MJ ;

O'Malley, BW .

CELL, 1999, 97 (01) :17-27

[9] Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes [J].

Lavinsky, RM ;

Jepsen, K ;

Heinzel, T ;

Torchia, J ;

Mullen, TM ;

Schiff, R ;

Del-Rio, AL ;

Ricote, M ;

Ngo, S ;

Gemsch, J ;

Hilsenbeck, SG ;

Osborne, CK ;

Glass, CK ;

Rosenfeld, MG ;

Rose, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (06) :2920-2925

[10]

Leygue E, 1999, CANCER RES, V59, P4190

← 1 2 →