Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth

被引：46

作者：

Hopper, A. P. ^{[1
]}

Dugan, J. M. ^{[1
]}

Gill, A. A. ^{[1
]}

Fox, O. J. L. ^{[2
]}

May, P. W. ^{[2
]}

Haycock, J. W. ^{[1
]}

Claeyssens, F. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Mat Sci & Engn, Sheffield S3 7HQ, S Yorkshire, England

[2] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

BIOMEDICAL MATERIALS | 2014年 / 9卷 / 04期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

nanodiamond; Schwann cells; neurons; functionalization; amine; peripheral nerve; DIAMOND NANOPARTICLES; PHOTOCHEMICAL FUNCTIONALIZATION; NANOCRYSTALLINE DIAMOND; MEMBRANES; COATINGS; BEHAVIOR; GROWTH; CELLS; ACID;

D O I：

10.1088/1748-6041/9/4/045009

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this study, we report the production of amine functionalized nanodiamond. The amine functionalized nanodiamond forms a conformal monolayer on a negatively charged surface produced via plasma polymerization of acrylic acid. Nanodiamond terminated surfaces were studied as substrates for neuronal cell culture. NG108-15 neuroblastoma-glyoma hybrid cells were successfully cultured upon amine functionalized nanodiamond coated surfaces for between 1 and 7 d. Additionally, primary dorsal root ganglion (DRG) neurons and Schwann cells isolated from Wistar rats were also successfully cultured over a period of 21 d illustrating the potential of the coating for applications in the treatment of peripheral nerve injury.

引用

页数：11

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