Pregnancy success rate at recurrent implantation failure patients after hysteroscopic endometrial injury: preliminary study

Purpose of Investigation: To assess better implantation and pregnancy rates following endometrial injury in the presence of previous implantation failure, through a retrospective study in a tertiary University Clinic. The aim of this study is to assess improved embryo implantation after hysteroscopic fundal endometrial injury in repeated implantation failure in patients. Materials and Methods: Twenty-nine women who had recurrent implantation failure participated in the study. They had three or more implantation failures with good quality embryo. Anti-Mullerian hormone (AMH) levels, age, antral follicle count, body mass index, and FSH levels were collected. Frozen/thawed embryos (FTE) were transferred in all subjects. Before embryo transfer the authors performed hysteroscopic endometrial injury by micro cold knife. Results: Median age was 38.62 +/- 2.47 years in the study. AMH levels changed between 0.35 and 3.8 ng/ml. The pregnancy rate following hysteroscopy: 17 (58,6%) were pregnant and 12 of 29 subjects did not become pregnant. The women who became pregnant following hysteroscopy were younger and had a higher antral follicle count than the non-pregnant women (p = 0.030 and p = 0.0017 respectively; p < 0.05). Conclusion: The endometrial injury before frozen-thawed embryo transfer had a positive effect on patients who had previous recurrent implantation failure.