One-pot oxidative Mannich-type reaction of lactams with alkyl malonates

被引：6
作者：
Matsuo, Jun-ichi [1 ]
Tanaki, Yumi [1 ]
Ishibashi, Hiroyuki [1 ]
机构：
[1] Kanazawa Univ, Grad Sch Nat Sci & Technol, Div Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 18期
关键词：
lactam; oxidation; Mannich-type reaction;
D O I：
10.1016/j.tetlet.2007.03.025
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One-pot substitution of a C-H bond at the position next to the nitrogen atom of lactams with alkyl malonates proceeded effectively by dehydrogenation of lactams with N-tert-butylbenzenesulfinimidoyl chloride, followed by Mannich-type addition of alkyl malonates. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3233 / 3236
页数：4
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