Fabrication of Triprolidine•HCl Transdermal Drug Delivery System and Pharmacokinetic Studies

The purpose was to examine and analyze the matrix system of Triprolidine center dot HCl wth the selected polymer ethyl cellulose. We achieved in vitro permeation studies using Keshary Chien diffusion cells across guinea pig skin. Considering the success of permeation enhancers with differing concentrations to enhance the permeation rate. The performed the in vitro dissolution of the developed transdermal patches. The in vivo analysis was carried out on male albino rabbits the drug release was determined by high performance liquid chromatography. The significant high performance liquid chromatography retention time of triprolidine center dot HCl was 4.0 min. The limit of detection was 10 ng/mL and quantification limit of was 17 ng/ml. The area under curve was found to be 646.39 ng/ml.hr with the Kel was 0.0682 and Ka was 0.184 hour-1. The peak plasma concentration 24.54 ng/ml were produced in peak time of 8.58 hrs with the half life of 10.