SUMO Boosts the DNA Damage Response Barrier against Cancer

被引：28

作者：

Bartek, Jiri ^{[1
,2
,3
]}

Hodny, Zdenek ^{[3
]}

机构：

[1] Danish Canc Soc, Inst Canc Biol, DK-2100 Copenhagen, Denmark

[2] Danish Canc Soc, Ctr Genotox Stress Res, DK-2100 Copenhagen, Denmark

[3] ASCR, Inst Mol Genet, Dept Genome Integr, VVI, CZ-14220 Prague, Czech Republic

来源：

CANCER CELL | 2010年 / 17卷 / 01期

关键词：

REPAIR;

D O I：

10.1016/j.ccr.2009.12.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cells exposed to genotoxic insults such as ionizing radiation activate a signaling cascade to repair the damaged DNA. Two recent articles published in Nature show that such genome maintenance requires modifications of tumor suppressor proteins BRCA1 and 53BP1 by the small ubiquitin-like modifier SUMO.

引用

页码：9 / 11

页数：3

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