The effects of repeated administration of camphor-crataegus berry extract combination on blood pressure and on attentional performance - A randomized, placebo-controlled, double-blind study

The present study investigated the effects of repeated administration of Korodin (R), a combination of camphor and crataegus berry extract, on blood pressure and attentional functioning. This study was conducted based on a randomized, placebo-controlled, double-blind design. 54 persons participated (33 female, 21 male) with a mean age of 24.3 years. Blood pressure and body mass index were in the normal range. Participants received 20 drops of either Korodin (R) or a placebo for four times with interjacent time intervals of about 10 min. Blood pressure was measured sphygmomanometrically before and after each administration. Attentional performance was quantified by using two paper-and-pencil tests, the d2 Test of Attention and Digit Symbol Test. Greater increases in blood pressure occurred after the four Korodin (R) administrations in comparison to the four placebo administrations. The performance in two parameters of d2 Test of Attention was consistently superior after the intake of Korodin (R). The excellent tolerability and safety of Korodin (R), even after a total consumption of 80 drops, was confirmed. (C) 2014 Elsevier GmbH. All rights reserved.