Epigenetic Biomarkers in Cardiovascular Diseases

被引：74

作者：

Soler-Botija, Carolina ^{[1
,2
]}

Galvez-Monton, Carolina ^{[1
,2
]}

Bayes-Genis, Antoni ^{[1
,2
,3
,4
]}

机构：

[1] Hlth Sci Res Inst Germans Trias i Pujol IGTP, Heart Failure & Cardiac Regenerat ICREC Res Progr, Badalona, Spain

[2] Inst Salud Carlos III, CIBERCV, Madrid, Spain

[3] HUGTiP, Cadiol Serv, Badalona, Spain

[4] Barcelona Autonomous Univ UAB, Dept Med, Badalona, Spain

来源：

FRONTIERS IN GENETICS | 2019年 / 10卷

关键词：

epigenetics; biomarker; microRNA; cardiovascular diseases; myocardial infarction; heart failure; atherosclerosis; hypertension; ACUTE MYOCARDIAL-INFARCTION; CIRCULATING P53-RESPONSIVE MICRORNAS; PULMONARY ARTERIAL-HYPERTENSION; DIFFERENTIAL DNA METHYLATION; EPIGENOME-WIDE ASSOCIATION; RENIN-ANGIOTENSIN SYSTEM; HUMAN HEART-FAILURE; CARDIAC TROPONIN-T; PROGNOSTIC VALUE; SEVERE PREECLAMPSIA;

D O I：

10.3389/fgene.2019.00950

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cardiovascular diseases are the number one cause of death worldwide and greatly impact quality of life and medical costs. Enormous effort has been made in research to obtain new tools for efficient and quick diagnosis and predicting the prognosis of these diseases. Discoveries of epigenetic mechanisms have related several pathologies, including cardiovascular diseases, to epigenetic dysregulation. This has implications on disease progression and is the basis for new preventive strategies. Advances in methodology and big data analysis have identified novel mechanisms and targets involved in numerous diseases, allowing more individualized epigenetic maps for personalized diagnosis and treatment. This paves the way for what is called pharmacoepigenetics, which predicts the drug response and develops a tailored therapy based on differences in the epigenetic basis of each patient. Similarly, epigenetic biomarkers have emerged as a promising instrument for the consistent diagnosis and prognosis of cardiovascular diseases. Their good accessibility and feasible methods of detection make them suitable for use in clinical practice. However, multicenter studies with a large sample population are required to determine with certainty which epigenetic biomarkers are reliable for clinical routine. Therefore, this review focuses on current discoveries regarding epigenetic biomarkers and its controversy aiming to improve the diagnosis, prognosis, and therapy in cardiovascular patients.

引用

页数：31

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