Control of NF-κB activation by the COP9 signalosome

被引：27

作者：

Schweitzer, Katrin ^{[1
]}

Naumann, Michael ^{[1
]}

机构：

[1] Otto VonGuericke Univ Magdegurg, Inst Expt Internal Med, Fac Med, D-39120 Magdeburg, Germany

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2010年 / 38卷

关键词：

Carma1-Bcl10-malt1 complex (CBM); cullin-RING ubiquitin ligase (CRL); deubiquitinase (DUB); inhibitor of nuclear factor kappa B (I kappa B); neural-precursor-cell-expressed developmentally down-regulated 8 (NEDD8); tumour necrosis factor receptor 1 (TNFR1); T-CELL DEVELOPMENT; ANTIGEN RECEPTOR; KINASE TAK1; CULLIN; BCL10; NEDD8; REGULATOR; LIGASE; MALT1; NEMO;

D O I：

10.1042/BST0380156

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcription factor NF-kappa B (nuclear factor kappa B) exerts crucial functions in the regulation of innate and adaptive immune responses, wound healing and tissue maintenance and in the development of immune cells. Tight control of NF-kappa B is essential for an efficient defence against pathogens and environmental stress to protect organisms from inflammatory diseases including cancer. An involvement of the CSN (COP9 signalosome) in the regulation of NF-kappa B has been discovered recently. The CSN is a conserved multiprotein complex, which mainly functions in the control of proteolysis. Here, we review recent observations indicating important roles of the CSN in the control of NF-kappa B in innate immunity, as well as T-cell activation and maturation.

引用

页码：156 / 161

页数：6

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