Photochemical and thermal Bergman cyclization of a pyrimidine enediynol and enediynone

被引：65

作者：

Choy, N

Blanco, B

Wen, JH

Krishan, A

Russell, KC

机构：

[1] Univ Miami, Dept Chem, Coral Gables, FL 33124 USA

[2] Univ Miami, Dept Radiat Oncol R71, Miami, FL 33101 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 24期

关键词：

D O I：

10.1021/ol006061j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel 10-membered pyrimidine enediynes (3 and 4) were synthesized in seven and eight steps, respectively. These compounds were compared for their abilities to undergo Bergman cyclization both thermally and photochemically, Alcohol 3 readily cyclized both thermally and photochemically in (PrOH)-Pr-i, while ketone 4 only showed efficient thermal cyclization, Both compounds were also shown to cleave dsDNA under the appropriate conditions.

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页码：3761 / 3764

页数：4

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