The role of exhaustion in CAR T cell therapy

被引：71

作者：

Delgoffe, Greg M. ^{[1
]}

Xu, Chenqi ^{[2
]}

Mackall, Crystal L. ^{[3
]}

Green, Michael R. ^{[4
]}

Gottschalk, Stephen ^{[5
]}

Speiser, Daniel E. ^{[6
]}

Zehn, Dietmar ^{[7
]}

机构：

[1] Univ Pittsburgh, Pittsburgh, PA 15260 USA

[2] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Beijing, Peoples R China

[3] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[4] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[5] St Jude Childrens Res Hosp, Memphis, TN USA

[6] Univ Lausanne, Lausanne, Switzerland

[7] Tech Univ Munich, Munich, Germany

来源：

CANCER CELL | 2021年 / 39卷 / 07期

关键词：

D O I：

10.1016/j.ccell.2021.06.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed.

引用

页码：885 / 888

页数：4