Immunohistochemical expression of cyclooxygenase-2 (COX-2) is not associated with tumor grade in feline meningiomas

被引：8

作者：

Samarani, F. ^{[1
,2
]}

de la Fuente, C. ^{[1
,2
]}

Parodi, A. ^{[4
]}

Mandara, M. T. ^{[3
]}

Pumarola, M. ^{[2
]}

Anor, S. ^{[1
,2
]}

机构：

[1] Univ Autonoma Barcelona, Fdn Hosp Clin, E-08193 Barcelona, Spain

[2] Univ Autonoma Barcelona, Dept Med & Cirurgia Anim, Fac Vet, E-08193 Barcelona, Spain

[3] Univ Perugia, Dept Vet Med, I-06120 Perugia, Italy

[4] Valos Srl, I-16121 Genoa, Italy

来源：

VETERINARY JOURNAL | 2018年 / 241卷

关键词：

Cats; COX-2; Immunohistochemistry; Meningioma; SURVIVAL;

D O I：

10.1016/j.tvjl.2018.09.009

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Meningioma is the most common primary brain tumor in cats and occurs less frequently in the spinal cord. This study aimed to investigate cyclooxygenase-2 (COX-2) expression in feline meningiomas, and the possible association between COX-2 immunoreactivity and tumor grade using eight low-grade and seven high-grade meningiomas. All tumors (n = 15/15) were immunoreactive to COX-2. The expression of COX-2 was not significantly correlated with tumor grade (P=0.22 and 0.34 for staining and intensity, respectively) but was significantly associated with necrosis (P=0.04 and 0.01 for staining and intensity, respectively). The findings in this study suggest that feline meningiomas express COX-2, but there were no differences in COX-2 immunoreactivity patterns between low- and high-grade meningiomas. However, the association between COX-2 expression and the presence of necrosis indicates a potential area for therapeutic intervention with selective COX-2 inhibitors. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：20 / 23

页数：4

共 14 条

[1] Immunohistochemical Detection of COX-2 in Feline and Canine Actinic Keratoses and Cutaneous Squamous Cell Carcinoma [J].