Spinal lesion as the first manifestation of high-grade B-cell lymphoma, with MYC and BCL2 rearrangements

被引：0

作者：

Ye, Yunxia ^{[1
]}

Zhang, Wenyan ^{[1
]}

Zhao, Sha ^{[1
]}

Jiang, Lili ^{[1
]}

Liu, Weiping ^{[1
]}

Long, Yanhong ^{[1
]}

Wan, Ying ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Pathol, Guoxue Alley 37, Chengdu 610001, Sichuan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2017年 / 10卷 / 08期

关键词：

Spinal; high-grade B-cell lymphoma; MYC; BCL2; gene rearrangement; DOUBLE-HIT LYMPHOMAS; POOR-PROGNOSIS; T(14/18); CLASSIFICATION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

High-grade B-cell lymphoma with MYC and BCL2 rearrangements is a rare lymphoma which has highly aggressive clinical manifestations. The reporting case is a 72-year-old female presented with lumbago and weakness in the lower limb due to a mass at T8-10 revealed by computed tomography (CT) scan. Histological feature of the lesion shows an abundant and diffuse large lymphoid cells infiltration. Immunophenotype meets with germ center B cell (GCB) lymphoma (Hans algorithm). C-MYC and BCL2 gene rearrangements are detected by fluorescence in situ hybridization (FISH). It's a rare and typical case of high-grade B-cell lymphoma with MYC and BCL2 rearrangements with uncommon clinical manifestation.

引用

页码：8858 / 8862

页数：5

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