Spinal lesion as the first manifestation of high-grade B-cell lymphoma, with MYC and BCL2 rearrangements

被引：0
|
作者：
Ye, Yunxia [1 ]
Zhang, Wenyan [1 ]
Zhao, Sha [1 ]
Jiang, Lili [1 ]
Liu, Weiping [1 ]
Long, Yanhong [1 ]
Wan, Ying [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Pathol, Guoxue Alley 37, Chengdu 610001, Sichuan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2017年 / 10卷 / 08期
关键词：
Spinal; high-grade B-cell lymphoma; MYC; BCL2; gene rearrangement; DOUBLE-HIT LYMPHOMAS; POOR-PROGNOSIS; T(14/18); CLASSIFICATION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
High-grade B-cell lymphoma with MYC and BCL2 rearrangements is a rare lymphoma which has highly aggressive clinical manifestations. The reporting case is a 72-year-old female presented with lumbago and weakness in the lower limb due to a mass at T8-10 revealed by computed tomography (CT) scan. Histological feature of the lesion shows an abundant and diffuse large lymphoid cells infiltration. Immunophenotype meets with germ center B cell (GCB) lymphoma (Hans algorithm). C-MYC and BCL2 gene rearrangements are detected by fluorescence in situ hybridization (FISH). It's a rare and typical case of high-grade B-cell lymphoma with MYC and BCL2 rearrangements with uncommon clinical manifestation.
引用
收藏
页码：8858 / 8862
页数：5
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