The potential regulatory role of vitamin D in the bioenergetics of inflammation

被引：51

作者：

Calton, Emily K. ^{[1
]}

Keane, Kevin N. ^{[2
]}

Soares, Mario J. ^{[1
]}

机构：

[1] Curtin Univ, Curtin Hlth Innovat Res Inst Ageing & Chron Dis, Sch Publ Hlth, GPO Box U1987, Perth, WA 6102, Australia

[2] Curtin Univ, Curtin Hlth Innovat Res Inst Ageing & Chron Dis, Sch Biomed Sci, Perth, WA 6102, Australia

来源：

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE | 2015年 / 18卷 / 04期

关键词：

bioenergetics; energy metabolism; inflammation; macrophage; obesity; vitamin D; METABOLIC SYNDROME; D SUPPLEMENTATION; MITOCHONDRIAL; ACTIVATION; MARKERS; OBESITY; MACROPHAGES; PLATELETS; PATHWAYS; RECEPTOR;

D O I：

10.1097/MCO.0000000000000186

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review The extraskeletal health benefits of vitamin D still need scientific endorsement. Obesity and related chronic diseases are pathogenically linked by inflammation, which carries a considerable energetic cost. Recent techniques for the determination of the bioenergetic demand of inflammation, offer an avenue to cement the regulatory role of vitamin D in this process. Recent findings Nuclear vitamin D receptors may be translocated into mitochondria of certain cell types, opening up a pathway for direct action on cellular bioenergetics. Classical M1 (inflammatory)/M2(anti-inflammatory) phenotypes can vary with the clinical context. M2 macrophages do not always depend on oxidative metabolism/fatty acid oxidation. Newer methodologies offer real-time bioenergetic measurements that can be used as an index of metabolic health. Summary Vitamin D may prove to be a therapeutic agent for inflammation of chronic disease and understanding its role in cellular bioenergetics may offer a diagnostic/prognostic indicator of its action.

引用

页码：367 / 373

页数：7

共 54 条

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