A short synthesis of naturally occurring and other analogues of plakinic acids that contain the 1,2-dioxolane group

被引：29

作者：

Bloodworth, AJ ^{[1
]}

Bothwell, BD ^{[1
]}

Collins, AN ^{[1
]}

Maidwell, NL ^{[1
]}

机构：

[1] ZENECA SPECIALTIES, MANCHESTER M9 8ZS, LANCS, ENGLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 11期

关键词：

D O I：

10.1016/0040-4039(96)00143-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Natural and unnatural analogues 4 of plakinic acids A, C and D have been prepared in three steps from alkan-2-ones by (i) LDA-induced condensation with ethyl 3-methylbut-2-enoate to give (2Z)-3,5-dimethylalka-2,4-dienoic acids 10, then (ii) isomerisation to the 2E-isomers 5 and finally (iii) peroxymercuriation with 30% hydrogen peroxide and reduction in situ with sodium borohydride.

引用

页码：1885 / 1888

页数：4

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