Static solid-state 2H NMR methods in studies of protein side-chain dynamics

被引：29

作者：

Vugmeyster, Liliya ^{[1
]}

Ostrovsky, Dmitry ^{[1
]}

机构：

[1] Univ Colorado, Denver, CO 80204 USA

来源：

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY | 2017年 / 101卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Protein dynamics; Static deuteron NMR; Solid-state NMR; Dynamical transitions; NUCLEAR-MAGNETIC-RESONANCE; SPIN-LATTICE-RELAXATION; METHYL-GROUP DYNAMICS; HYDROPHOBIC CORE; LINE-SHAPES; QUADRUPOLAR NUCLEI; RING DYNAMICS; BROAD-BAND; MOTIONS; SPECTROSCOPY;

D O I：

10.1016/j.pnmrs.2017.02.001

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this review, we discuss the experimental static deuteron NMR techniques and computational approaches most useful for the investigation of side-chain dynamics in protein systems. Focus is placed on the interpretation of line shape and relaxation data within the framework of motional modeling. We consider both jump and diffusion models and apply them to uncover glassy behaviors, conformational exchange and dynamical transitions in proteins. Applications are chosen from globular and membrane proteins, amyloid fibrils, peptide adsorbed on surfaces and proteins specific to connective tissues. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：1 / 17

页数：17

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