Enantioselective alkynylation of aromatic ketones catalyzed by new chiral oxazolidine ligands

被引：60
作者：
Kang, YF
Liu, L
Wang, R
Zhou, YF
Yan, WJ
机构：
[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Sch Life Sci, Dept Biochem & Mol Biol, Lanzhou 730000, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2005年 / 347卷 / 2-3期
关键词：
addition to ketones; alkynes; asymmetric catalysis; C-C bond formation; oxazolidines; propargylic alcohols;
D O I：
10.1002/adsc.200404278
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
New chiral oxazolidine ligands have been derived conveniently from natural amino acids in good yields. Their use in the enantioselective addition of phenylacetylene to aromatic ketones has been tested with the best ee being up to 88%. We provide a simple, practical and inexpensive method to generate chiral tertiary propargylic alcohols.
引用
收藏
页码：243 / 247
页数：5
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