Gut-Liver Axis Links Portal Hypertension to Acute-on-Chronic Liver Failure

被引：44
作者：
Trebicka, Jonel [1 ,2 ,3 ,4 ]
Reiberger, Thomas [5 ,6 ]
Laleman, Wim [7 ,8 ]
机构：
[1] Univ Bonn, Dept Internal Med 1, Bonn, Germany
[2] European Fdn Study Chron Liver Failure, Barcelona, Spain
[3] Univ Southern Denmark, Fac Hlth Sci, Odense, Denmark
[4] Inst Bioengn Catalonia, Barcelona, Spain
[5] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Vienna, Austria
[6] Med Univ Vienna, Vienna Hepat Hemodynam Lab, Vienna, Austria
[7] Katholieke Univ Leuven, Hosp Gasthuisberg, Dept Gastroenterol & Hepatol, Liver & Biliopancreat Sect, Leuven, Belgium
[8] Katholieke Univ Leuven, Lab Hepatol, Dept Chron Dis Metab & Ageing CHROMETA, Leuven, Belgium
来源：
VISCERAL MEDICINE | 2018年 / 34卷 / 04期
基金：
欧盟地平线“2020”;
关键词：
Portal hypertension; Systemic inflammation; Acute-on-chronic liver failure; ACLF; Microbiome; Bacterial translocation; SPONTANEOUS BACTERIAL PERITONITIS; HEPATORENAL-SYNDROME; CIRRHOTIC-PATIENTS; DECOMPENSATED CIRRHOSIS; PRIMARY PROPHYLAXIS; SYSTEMIC INFLAMMATION; RIFAXIMIN IMPROVES; BETA-BLOCKERS; ALBUMIN; MICROBIOME;
D O I：
10.1159/000490262
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Acute-on-chronic liver failure (ACLF) is considered a distinct syndrome in patients with liver disease, with systemic inflammation playing a central role. Portal hyper-tension (PHT) is also aggravated by inflammation and may subsequently impact the course of ACLF. PHT is more than just an increase in portal pressure in the portal venous system; it aggravates the course of liver disease and, thus, also facilitates the development of acute decompensation and ACLF. A critical mechanistic link between PHT and ACLF might be the gut-liver axis, which is discussed in this review. (C) 2018 S Karger GmbH, Freiburg
引用
收藏
页码：270 / 275
页数：6
相关论文
共 74 条
[1]   Gut Microbiota and Complications of Liver Disease [J].
Acharya, Chathur ;
Bajaj, Jasmohan S. .
GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 2017, 46 (01) :155-+
[2]   Epidemiology and Healthcare Burden of Acute-on-Chronic Liver Failure [J].
Allen, Alina M. ;
Kim, W. Ray .
SEMINARS IN LIVER DISEASE, 2016, 36 (02) :123-126
[3]   Acute-on-chronic liver failure in cirrhosis [J].
Arroyo, Vicente ;
Moreau, Richard ;
Kamath, Patrick S. ;
Jalan, Rajiv ;
Gines, Pere ;
Nevens, Frederik ;
Fernandez, Javier ;
To, Uyen ;
Garcia-Tsao, Guadalupe ;
Schnabl, Bernd .
NATURE REVIEWS DISEASE PRIMERS, 2016, 2 :1-18
[4]   Human serum albumin, systemic inflammation, and cirrhosis [J].
Arroyo, Vicente ;
Garcia-Martinez, Rita ;
Salvatella, Xavier .
JOURNAL OF HEPATOLOGY, 2014, 61 (02) :396-407
[5]   Tying up PGE2 with albumin to relieve immunosuppression in cirrhosis [J].
Arroyo, Vicente ;
Moreau, Richard .
NATURE MEDICINE, 2014, 20 (05) :467-469
[6]   Acute-On-Chronic Liver Failure [J].
Asrani, Sumeet. K. ;
O'Leary, Jacqueline G. .
CLINICS IN LIVER DISEASE, 2014, 18 (03) :561-+
[7]   Survival in Infection-Related Acute-on-Chronic Liver Failure Is Defined by Extrahepatic Organ Failures [J].
Bajaj, Jasmohan S. ;
O'Leary, Jacqueline G. ;
Reddy, K. Rajender ;
Wong, Florence ;
Biggins, Scott W. ;
Patton, Heather ;
Fallon, Michael B. ;
Garcia-Tsao, Guadalupe ;
Maliakkal, Benedict ;
Malik, Raza ;
Subramanian, Ram M. ;
Thacker, Leroy R. ;
Kamath, Patrick S. .
HEPATOLOGY, 2014, 60 (01) :250-256
[8]   Second Infections Independently Increase Mortality in Hospitalized Patients With Cirrhosis: The North American Consortium for the Study of End-Stage Liver Disease (NACSELD) Experience [J].
Bajaj, Jasmohan S. ;
O'Leary, Jacqueline G. ;
Reddy, K. Rajender ;
Wong, Florence ;
Olson, Jody C. ;
Subramanian, Ram M. ;
Brown, Geri ;
Noble, Nicole A. ;
Thacker, Leroy R. ;
Kamath, Patrick S. .
HEPATOLOGY, 2012, 56 (06) :2328-2335
[9]   Chemokine (C-X-C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt [J].
Berres, Marie-Luise ;
Lehmann, Jennifer ;
Jansen, Christian ;
Goertzen, Jan ;
Meyer, Carsten ;
Thomas, Daniel ;
Zimmermann, Henning W. ;
Kroy, Daniela ;
Schumacher, Fabienne ;
Strassburg, Christian P. ;
Sauerbruch, Tilman ;
Trautwein, Christian ;
Wasmuth, Hermann E. ;
Trebicka, Jonel .
LIVER INTERNATIONAL, 2016, 36 (03) :386-394
[10]   CXCL9 is a prognostic marker in patients with liver cirrhosis receiving transjugular intrahepatic portosystemic shunt [J].
Berres, Marie-Luise ;
Asmacher, Sonja ;
Lehmann, Jennifer ;
Jansen, Christian ;
Goertzen, Jan ;
Klein, Sabine ;
Meyer, Carsten ;
Strunk, Holger M. ;
Fimmers, Rolf ;
Tacke, Frank ;
Strassburg, Christian P. ;
Trautwein, Christian ;
Sauerbruch, Tilman ;
Wasmuth, Hermann Elard ;
Trebicka, Jonel .
JOURNAL OF HEPATOLOGY, 2015, 62 (02) :332-339
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