An expedient sequential one-pot four component synthesis of novel steroidal spiro-pyrrolidine heterocycles in ionic liquid

被引：20
作者：
Gavaskar, D. [1 ]
Babu, A. R. Suresh [2 ]
Raghunathan, R. [1 ]
Dharani, M. [3 ]
Balasubramanian, S. [3 ]
机构：
[1] Univ Madras, Dept Organ Chem, Guindy Campus, Madras, Tamil Nadu, India
[2] Univ Strasbourg, IBMC, Strasbourg, France
[3] Univ Madras, Dept Inorgan Chem, Guindy Campus, Madras, Tamil Nadu, India
来源：
STEROIDS | 2016年 / 109卷
关键词：
Estrone; Ionic liquid; Azomethine ylide; Cycloaddition; Indenoquinoxaline; Steroidal pyrrolidine; MEDIATED 3+2 CYCLOADDITION; BIOLOGICAL-ACTIVITY; MULTICOMPONENT REACTIONS; AZOMETHINE YLIDES; DERIVATIVES; FACILE; ANTIBACTERIAL; ESTRONE; LIPS; CONSTRUCTION;
D O I：
10.1016/j.steroids.2016.02.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A facile one-pot synthesis of novel steroidal dispiro-indenoquinoxaline pyrrolidines via multicomponent-[3+2]-cycloaddition of azomethine ylides in ionic liquid is described. The structure of cycloadduct is confirmed by IR, H-1 NMR, C-13 NMR, high resolution mass spectroscopy and elemental analysis. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：1 / 6
页数：6
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