Hippocampal Plasticity during the Peripartum Period: Influence of Sex Steroids, Stress and Ageing

被引：74
作者：
Galea, L. A. M. [1 ]
Leuner, B. [2 ,3 ]
Slattery, D. A. [4 ]
机构：
[1] Univ British Columbia, Dept Psychol, Vancouver, BC, Canada
[2] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA
[3] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA
[4] Univ Regensburg, Dept Behav & Mol Neurobiol, D-93053 Regensburg, Germany
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 2014年 / 26卷 / 10期
关键词：
lactation; postpartum; neurogenesis; corticosterone; cognition; depression; PITUITARY-ADRENAL AXIS; CA3 PYRAMIDAL NEURONS; CELL-PROLIFERATION; REPRODUCTIVE EXPERIENCE; ADULT NEUROGENESIS; ALZHEIMERS-DISEASE; MATERNAL-BEHAVIOR; POSTPARTUM PERIOD; SPATIAL MEMORY; ANIMAL-MODEL;
D O I：
10.1111/jne.12177
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The peripartum period is accompanied by dramatic changes in hormones and a host of new behaviours in response to experience with offspring. Both maternal experience and maternal hormones can have a significant impact upon the brain and behaviour. This review outlines recent studies demonstrating modifications in hippocampal plasticity across the peripartum period, as well as the putative hormonal mechanisms underlying these changes and their modulation by stress. In addition, the impact of reproductive experience upon the ageing hippocampus is discussed. Finally, we consider how these changes in hippocampal structure may play a role in postpartum cognitive function and mood disorders, as well as age-related cognitive decline.
引用
收藏
页码：641 / 648
页数：8
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