Antibacterial anthraquinone derivatives isolated from a mangrove-derived endophytic fungus Aspergillus nidulans by ethanol stress strategy

被引:34
|
作者
Yang, Sui-Qun [1 ,2 ]
Li, Xiao-Ming [1 ]
Xu, Gang-Ming [1 ]
Li, Xin [1 ]
An, Chun-Yan [1 ]
Wang, Bin-Gui [1 ]
机构
[1] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Lab Marine Biol & Biotechnol,Qingdao Natl Lab Mar, Nanhai Rd 7, Qingdao, Peoples R China
[2] Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing, Peoples R China
来源
JOURNAL OF ANTIBIOTICS | 2018年 / 71卷 / 09期
关键词
POLYKETIDES; METABOLITES;
D O I
10.1038/s41429-018-0063-x
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Three new natural products, including a new anthraquinone derivative isoversicolorin C (1), a new xanthone analog isosecosterigmatocystin (2), and a new amino acid derivative, glulisine A (3), along with six related metabolites (4-9) were isolated from the culture broth and mycelia extracts of the mangrove-derived endophytic fungus Aspergillus nidulans MA-143 under 0.1% ethanol stress. Their structures were elucidated by detailed analysis of their NMR spectra, ECD spectrum, and X-ray crystallographic experiments. Compounds 1 and 4 showed potent antibacterial activity against some of the tested microbes.
引用
收藏
页码:778 / 784
页数:7
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