Highly compatible metal and enzyme catalysts for efficient dynamic kinetic resolution of alcohols at ambient temperature

被引：173

作者：

Martín-Matute, B ^{[1
]}

Edin, M ^{[1
]}

Bogár, K ^{[1
]}

Bäckvall, JE ^{[1
]}

机构：

[1] Univ Stockholm, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 47期

关键词：

enantioselectivity; enzyme catalysis; kinetic resolution; reaction mechanisms; ruthenium;

D O I：

10.1002/anie.200461416

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical equation presented). The combination of highly compatible metal and enzyme catalysts allows the fastest dynamic kinetic resolution of alcohols ever reported. The use of ruthenium catalyst 1a (or 1b) and an immobilized lipase results in a highly efficient enantioselective synthesis of acetates in excellent yields at room temperature (see scheme).

引用

页码：6535 / 6539

页数：5

共 53 条

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