A rhodium-catalysed three-component reaction to access C1-substituted tetrahydroisoquinolines

被引：8

作者：

Zhang, Dan ^{[1
]}

Liu, Junwen ^{[1
]}

Kang, Zhenghui ^{[1
]}

Qiu, Huang ^{[1
]}

Hu, Wenhao ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Guangdong, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 46期

基金：

中国国家自然科学基金;

关键词：

C; N-CYCLIC AZOMETHINE IMINES; ENANTIOSELECTIVE 1,3-DIPOLAR CYCLOADDITION; EFFICIENT; PRAZIQUANTEL; ANNULATION; ALDEHYDES; YLIDES; SALTS;

D O I：

10.1039/c9ob02303h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rhodium-catalyzed three-component reaction of diazo compounds, anilines and C,N-cyclic azomethine imines via trapping of transient ammonium ylides was developed. This reaction provided a simple and convenient approach for the synthesis of pharmaceutically intriguing tetrahydroisoquinoline derivatives in moderate to good yields (36-85%) with good diastereoselectivities (up to 95 : 5 dr) under mild reaction conditions.

引用

页码：9844 / 9848

页数：5

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