Effect of the aminosteroid U73122 on prostaglandin E2 production in a murine clonal osteoblast-like cell line, MC3T3-E1

被引：1

作者：

Leis, HJ ^{[1
]}

Köfeler, H ^{[1
]}

Raspotnig, G ^{[1
]}

Zach, D ^{[1
]}

Fauler, G ^{[1
]}

Windischhofer, W ^{[1
]}

机构：

[1] Graz Univ, Childrens Hosp, Dept Biochem Anal & Mass Spectrometry, A-8036 Graz, Austria

来源：

BIOCHEMICAL PHARMACOLOGY | 2000年 / 60卷 / 07期

关键词：

U73122; phospholipase C; osteoblast;

D O I：

10.1016/S0006-2952(00)00401-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prostaglandin E-2 production stimulated by various agents (arachidonic acid, prostaglandin F-2 alpha, ionomycin, the calcium ionophore A23187, and melittin) was investigated after pretreatment of murine osteoblast-like MC3T3-E1 cells with the putative phospholipase C blocker, U73122. The aminosteroid dose dependently inhibited prostaglandin E-2 production induced by all agonists, except arachidonic acid. The results suggest an inhibitory role of U73122 on phospholipase A(2) activity or activation BIOCHEM PHARMACOL 60;7:899-904, 2000. (C) 2000 Elsevier Science Inc.

引用

页码：899 / 904

页数：6