Expeditious Approach to Indoloquinazolinones via Double Annulations of o-Aminoacetophenones and Isocyanates

被引：11

作者：

Ding, Yuxin ^{[1
,2
,3
]}

Yan, Huihui ^{[3
]}

Chen, Rener ^{[1
,2
]}

Xiao, Xuqiong ^{[4
]}

Wang, Zhiming ^{[1
,2
]}

Wang, Lei ^{[1
,2
]}

Ma, Yongmin ^{[1
,2
,3
]}

机构：

[1] Taizhou Univ, Inst Adv Studies, Taizhou 318000, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Peoples R China

[3] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Peoples R China

[4] Hangzhou Normal Univ, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou 311121, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 02期

关键词：

SIMPLE INDOLE ALKALOIDS; CATALYZED C-H; FUNCTIONALIZATION; DERIVATIVES; CYCLIZATION; TRYPTANTHRIN; QUINAZOLINE; SCAFFOLDS; PROGRESS;

D O I：

10.1021/acs.joc.0c02155

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel procedure for a one-pot cascade reaction of o-aminoacetophenones and aryl/aliphatic isocyanates catalyzed/oxidized by the [Pd]/[Ag] system was developed. The reaction involves two C-N bond and one C-C bond formations during the double annulation process and the desired indoloquinazolinones and derivatives were afforded up to 81% yields from readily available substrates with a tolerance of a broad variety.

引用

页码：1448 / 1455

页数：8

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