Heterotopias, cortical dysplasias and glioneural tumors participate in cognitive processing in patients with temporal lobe epilepsy

被引：14
作者：
Kirschstein, T
Fernández, G
Grunwald, T
Pezer, N
Urbach, H
Blümcke, I
Van Roost, D
Lehnertz, K
Elger, CE
机构：
[1] Univ Bonn, Dept Epileptol, D-53105 Bonn, Germany
[2] Univ Bonn, Dept Neuroradiol, D-53105 Bonn, Germany
[3] Dept Neuropathol, D-91054 Erlangen, Germany
[4] Univ Bonn, Dept Neurosurg, D-53105 Bonn, Germany
来源：
NEUROSCIENCE LETTERS | 2003年 / 338卷 / 03期
关键词：
event-related potentials; depth electrodes; dysplastic brain lesions; epilepsy;
D O I：
10.1016/S0304-3940(02)01398-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Focal brain lesions such as cortical dysplasia and glioneural tumors generate epileptic activity and thus may be synaptically connected with normal cortex. To test this hypothesis, we compared event-related potentials recorded directly from the medial temporal lobe (MTL) and a dysplastic lesion in eight patients with intractable temporal lobe epilepsy. The P3 component, related to visual target detection, showed different peak latencies in four patients and a larger intralesional amplitude compared to established anterior-MTL-generators in two patients. Semantic processing was identified by the N400 component and showed a different latency in four patients and larger intralesional amplitudes in two patients. These results are compatible with the hypothesis that cortical lesions interact with synaptic pathways related to cognitive functions such as visual target detection, and verbal processing. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：237 / 241
页数：5
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