Cadmium-induced changes in cation-osmotic haemolysis in rats

被引：12
|
作者：
Ján, M
Frantisek, N
机构：
[1] Safarik Univ, Fac Med, Dept Pharmacol, Kosice 04066, Slovakia
[2] Safarik Univ, Fac Med, Dept Pathophysiol, Kosice 04066, Slovakia
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2000年 / 8卷 / 02期
关键词：
cadmium; cation-osmotic haemolysis; specktrine skeleton; membrane proteins;
D O I：
10.1016/S1382-6689(99)00036-8
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Erythrocyte microrheology changes were measured using cation-osmotic haemolysis (COH) in healthy rats and rats after 6 and 12 months of cadmium ingestion. Using COH properties of two membrane constituents, spectrine membrane skeleton and membrane bilayer, were studied. COH in rats after 6 months of cadmium ingestion was significantly lower only in the area with lower ionic strength. However, longer intake of cadmium (12 months) induced decrease of COH in both areas, with lower and also with higher ionic strength. The relation between cation-osmotic haemolysis and erythrocyte deformability is being discussed. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：79 / 81
页数：3
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