Synthesis and cytotoxic activity of trisubstituted-1,3,5-triazines

被引：58

作者：

Arya, Kapil ^{[1
]}

Dandia, Anshu

机构：

[1] R&D Ctr, Indian Oil Corp Ltd, Faridabad 121007, Haryana, India

[2] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 12期

关键词：

phototoxicity; MW irradiation; photosynthesis-inhibiting; ONE-POT SYNTHESIS; GREEN CHEMICAL-SYNTHESIS; CARBONYL-COMPOUNDS; ORGANIC-SYNTHESIS; ZEOLITE HSZ-360; AQUEOUS-MEDIUM; DERIVATIVES; MICROWAVES; INHIBITORS; CATALYST;

D O I：

10.1016/j.bmcl.2007.04.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1, 3,5-Triazine derivatives were screened for phototoxicity as well as the cytotoxic activities against leukemia and adenocarcinoma derived cell lines in comparison to the normal human keratinocytes. A simple and environmentally friendly procedure has been developed for the synthesis of 1,3,5-triazine derivatives under microwave irradiation in the presence of a HY zeolite. The catalyst can be recovered and reused. Thus, the procedure provides a simple and green synthetic methodology under environmentally friendly conditions. Structure-activity relationships between the chemical structures and antimycobacterial and photosynthesis-inhibiting activity of the evaluated compounds are also discussed. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3298 / 3304

页数：7

共 59 条

[1] Synthesis of biologically important novel fluorinated spiro heterocycles under microwaves catalyzed by montmorillonite KSF [J].

Arya, Kapil ;

Dandia, Anshu .

JOURNAL OF FLUORINE CHEMISTRY, 2007, 128 (03) :224-231

[2] Microwave prompted multigram synthesis, structural determination, and photo-antiproliferative activity of fluorinated 4-hydroxyquinolinones [J].

Arya, Kapil ;

Agarwal, Manish .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (01) :86-93

[3] On the kinetics and energetics of one-electron oxidation of 1,3,5-triazines [J].

Azenha, MEDG ;

Burrows, HD ;

Canle, M ;

Coimbra, R ;

Fernández, MI ;

García, MV ;

Rodrigues, AE ;

Santaballa, JA ;

Steenken, S .

CHEMICAL COMMUNICATIONS, 2003, (01) :112-113

[4] One-pot synthesis of tetrasubstituted imidazoles catalyzed by zeolite HY and silica gel under microwave irradiation [J].

Balalaie, S ;

Arabanian, A .

GREEN CHEMISTRY, 2000, 2 (06) :274-276

[5] Solvent free synthesis and deprotection of 1,1-diacetates over a commercially available zeolite Y as a reusable catalyst [J].

Ballini, R ;

Bordoni, M ;

Bosica, G ;

Maggi, R ;

Sartori, G .

TETRAHEDRON LETTERS, 1998, 39 (41) :7587-7590

[6] 1,3-dioxolanes from carbonyl compounds over zeolite HSZ-360 as a reusable, heterogeneous catalyst [J].

Ballini, R ;

Bosica, G ;

Frullanti, B ;

Maggi, R ;

Sartori, G ;

Schroer, F .

TETRAHEDRON LETTERS, 1998, 39 (12) :1615-1618

[7] Zeolite HSZ-360 as a new reusable catalyst for the direct acetylation of alcohols and phenols under solventless conditions [J].

Ballini, R ;

Bosica, G ;

Carloni, S ;

Ciaralli, L ;

Maggi, R ;

Sartori, G .

TETRAHEDRON LETTERS, 1998, 39 (33) :6049-6052

[8] Evaluation and optimisation of the reagent addition sequence during the synthesis of atrazine (6-chloro-N2-ethyl-N4-isopropyl-1,3,5-triazine-2,4-diamine) using reaction calorimetry [J].

Barton, B ;

Gouws, S ;

Schaefer, MC ;

Zeelie, B .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2003, 7 (06) :1071-1076

[9]

Bernard AM, 1997, SYNTHESIS-STUTTGART, P41

[10] MORE chemistry for less pollution: Applications for process development [J].

Bose, AK ;

Manhas, MS ;

Ganguly, SN ;

Sharma, AH ;

Banik, BK .

SYNTHESIS-STUTTGART, 2002, (11) :1578-1591

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