Professional killers: The role of extracellular vesicles in the reciprocal interactions between natural killer, CD8+ cytotoxic T-cells and tumour cells

被引：44
作者：
Del Vecchio, Filippo [1 ]
Martinez-Rodriguez, Verena [1 ,2 ]
Schukking, Monique [1 ,3 ]
Cocks, Alexander [1 ]
Broseghini, Elisabetta [1 ,4 ]
Fabbri, Muller [1 ]
机构：
[1] Univ Hawaii Manoa, Canc Biol Program, Univ Hawaii Canc Ctr, 701 Ilalo St,Room338, Honolulu, HI 96813 USA
[2] Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96822 USA
[3] Univ Hawaii Manoa, Dept Mol Biosci & Bioengn, Honolulu, HI 96822 USA
[4] Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy
来源：
JOURNAL OF EXTRACELLULAR VESICLES | 2021年 / 10卷 / 06期
基金：
美国国家卫生研究院;
关键词：
cancer; CTLs; extracellular vesicles; immune system; NK cells; DOWN-REGULATION; SELECTIVE EXPRESSION; IMMUNE SURVEILLANCE; PROGENITOR CELLS; DENDRITIC CELLS; LARGE ONCOSOMES; MESSENGER-RNAS; MHC MOLECULES; EXOSOMES; EFFECTOR;
D O I：
10.1002/jev2.12075
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Extracellular vesicles (EVs) mediate the cross-talk between cancer cells and the cells of the surrounding Tumour Microenvironment (TME). Professional killer cells include Natural Killer (NK) cells and CD8+ Cytotoxic T-lymphocytes (CTLs), which represent some of the most effective immune defense mechanisms against cancer cells. Recent evidence supports the role of EVs released by NK cells and CTLs in killing cancer cells, paving the road to a possible therapeutic role for such EVs. This review article provides the state-of-the-art knowledge on the role of NK- and CTL-derived EVs as anticancer agents, focusing on the different functions of different subtypes of EVs. We also reviewed the current knowledge on the effects of cancer-derived EVs on NK cells and CTLs, identifying areas for future investigation in the emerging new field of EV-mediated immunotherapy of cancer.
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页数：18
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