Validation of the NCCN-IPI and the GELTAMO-IPI for diffuse large B-Cell lymphoma treated with R-CHOP in a large cohort of patients from a single institution

被引：6

作者：

Queralt Salas, Maria ^{[1
]}

Mercadal, Santiago ^{[1
]}

Domingo Domenech, Eva ^{[1
]}

Carla Oliveira, Ana ^{[1
]}

Encuentra, Maite ^{[1
]}

Climent, Fina ^{[2
]}

Andrade Campos, Marcio ^{[1
]}

Aguilera, Carmen ^{[1
]}

Fernandez de Sevilla, Alberto ^{[1
]}

Sureda, Anna ^{[1
]}

Gonzalez-Barca, Eva ^{[1
]}

机构：

[1] Inst Catala Oncol ICO Hosp, Dept Clin Haematol, Barcelona, Spain

[2] Univ Hosp Bellvitge IDIBELL, Dept Pathol, Barcelona, Spain

来源：

LEUKEMIA & LYMPHOMA | 2019年

关键词：

Diffuse large B-cell lymphoma; NCCN-IPI; GELTAMO-IPI; IPI; pronostic factor; CHEMOTHERAPY PLUS RITUXIMAB; ELDERLY PATIENTS; DLBCL; PROGNOSIS; BETA-2-MICROGLOBULIN; CLASSIFICATION; SURVIVAL; ACCURATE; RISK; ERA;

D O I：

10.1080/10428194.2019.1683733

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The discriminative power of International Prognostic Index (IPI) in diffuse large B-cell lymphoma (DLBCL) decreased with the addition of rituximab to chemotherapy. The National Comprehensive Cancer Network (NCCN)-IPI and the Grupo Espanol de Linfomas y Trasplante Autologo de Medula & Oacute; sea (GELTAMO)-IPI were developed to improve the risk prediction for DLBCL patients. We aim to validate the NCCN-IPI and GELTAMO-IPI in a large and homogeneous cohort of 337 DLBCL patients treated with curative intent with R-CHOP/R-CHOP-like immunochemotherapy. The IPI stratifies patients in two independent risk groups and the estimated 5-year overall survival (OS) of the high-risk (HR) group was 43%. NCCN-IPI discriminated four risk groups and GELTAMO-IPI three risk groups of patients. The predicted 5-year OS of the HR group was 38% and 29%, respectively. NCCN-IPI and GELTAMO-IPI are more accurate prognostic indices than IPI in DBLCL patients treated with immunochemotherapy. GELTAMO-IPI demonstrated enhanced discrimination than NCCN-IPI for the higher-risk population.

引用

页码：575 / 581

页数：7

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